Publications
- Barath A.S.*, Dheer A*, Montier L, Wu LJ et al. Microglial SWELL1 deficiency drives male-specific seizure vulnerability but paradoxical neuroprotection through impaired phagocytosis. JCI Insight. 2026;11(12):e197980. doi.org/10.1172/jci.insight.197980. *co–first authors.
- Bosco DB, Kremen V, Haruwaka K, Zhao S, Wang L, Ebner BA, Zheng J, Xie M, Dheer A, Perry JF, Barath A, Nguyen AT, Worrell GA, Wu LJ. Microglial TREM2 promotes phagocytic clearance of damaged neurons after status epilepticus. Brain Behav Immun. 2025 Jan;123:540-555. doi: 10.1016/j.bbi.2024.09.034.
- Zheng J, Wang L, Zhao S, Zhang W, Chang Y, Bosco DB, Huang T, Dheer A, Gao S, Xu S, Ayasoufi K, Al-Kharboosh R, Qi F, Xie M, Johnson AJ, Dong H, Quiñones-Hinojosa A, Wu LJ. TREM2 mediates MHCII-associated CD4+ T-cell response against gliomas. Neuro Oncol. 2024 May 3;26(5):811-825. doi: 10.1093/neuonc/noad214.
- Dheer A, Bosco DB, Zheng J, Wang L, Zhao S, Haruwaka K, Yi MH, Barath A, Tian DS, Wu LJ. Chemogenetic approaches reveal dual functions of microglia in seizures. Brain Behav Immun. 2024 Jan;115:406-418. doi: 10.1016/j.bbi.2023.11.002.
- Zhao S, Zheng J, Wang L, Umpierre AD, Parusel S, Xie M, Dheer A, Ayasoufi K, Johnson AJ, Richardson JR, Wu LJ. Chemogenetic manipulation of CX3CR1(+) cells transiently induces hypolocomotion independent of microglia. Mol Psychiatry. 2023 Jul;28(7):2857-2871. doi: 10.1038/s41380-023-02128-6.
- Dheer A. et. al. 2022. Glia in Epilepsy: An Overview. In: Patro, I., Seth, P., Patro, N., Tandon, P.N. (eds) The Biology of Glial Cells: Recent Advances. Springer, Singapore. https://doi.org/10.1007/978-981-16-8313-8_12. (book chapter)
- Kushwah N, Jain V, Kadam M, Kumar R, Dheer A, Prasad D, Kumar B, Khan N. Ginkgo biloba L. Prevents Hypobaric Hypoxia-Induced Spatial Memory Deficit Through Small Conductance Calcium-Activated Potassium Channel Inhibition: The Role of ERK/CaMKII/CREB Signaling. Front Pharmacol. 2021;12:669701. doi: 10.3389/fphar.2021.669701.
- Kumar R, Jain V, Kushwah N, Dheer A, Mishra KP, Prasad D, Singh SB. HDAC inhibition prevents hypobaric hypoxia-induced spatial memory impairment through PΙ3K/GSK3β/CREB pathway. J Cell Physiol. 2021 Sep;236(9):6754-6771. doi: 10.1002/jcp.30337.
- Yi MH, Liu YU, Umpierre AD, Chen T, Ying Y, Zheng J, Dheer A, Bosco DB, Dong H, Wu LJ. Optogenetic activation of spinal microglia triggers chronic pain in mice. PLoS Biol. 2021 Mar;19(3):e3001154. doi: 10.1371/journal.pbio.3001154.
- Wei Y, Chen T, Bosco DB, Xie M, Zheng J, Dheer A, Ying Y, Wu Q, Lennon VA, Wu LJ. The complement C3-C3aR pathway mediates microglia-astrocyte interaction following status epilepticus. Glia. 2021 May;69(5):1155-1169. doi: 10.1002/glia.23955. Epub 2020 Dec 14.
- Kushwah N, Jain V, Dheer A, Kumar R, Prasad D, Khan N. Hypobaric Hypoxia-Induced Learning and Memory Impairment: Elucidating the Role of Small Conductance Ca(2+)-Activated K(+) Channels. Neuroscience. 2018 Sep 15;388:418-429. doi: 10.1016/j.neuroscience.2018.07.026.
- Kumar R, Jain V, Kushwah N, Dheer A, Mishra KP, Prasad D, Singh SB. Role of DNA Methylation in Hypobaric Hypoxia-Induced Neurodegeneration and Spatial Memory Impairment. Ann Neurosci. 2018 Dec;25(4):191-200. doi: 10.1159/000490368. .
- Dheer A, Jain V, Kushwah N, Kumar R, Prasad D, Singh SB. Temporal and Spatial Changes in Glial Cells During Chronic Hypobaric Hypoxia: Role in Neurodegeneration. Neuroscience. 2018 Jul 15;383:235-246. doi: 10.1016/j.neuroscience.2018.04.026.